Buffalo (2-2) rushed out to a 20-6 halftime lead, highlighted by a 42 yard touchdown pass from EJ Manuel to Robert Woods.
The Ravens (2-2) only had nine rushing attempts gaining 24 yards on the ground.
Torrey Smith had five catches for 166 yards and a touchdown in the loss.
Copyright 2013 ABC News Radio
Eliott C. McLaughlin, CNN Newswire
Jill Martin, CNN